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Effect of a Cellulose‐containing Weight‐loss Supplement on Gastric Emptying and Sensory Functions
Author(s) -
Berthold Heiner K.,
Unverdorben Susanne,
Degenhardt Ralf,
Unverdorben Martin,
GouniBerthold Ioanna
Publication year - 2008
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2008.355
Subject(s) - gastric emptying , postprandial , crossover study , medicine , meal , placebo , weight loss , appetite , ingestion , stomach , breath test , analysis of variance , gastroenterology , zoology , obesity , helicobacter pylori , alternative medicine , pathology , insulin , biology
CM3, a highly cross‐linked cellulose in capsule form, expands in the stomach to a size several fold of its original volume. It is purported to induce a prolonged feeling of satiation and a delay in gastric emptying, thus promoting weight loss. We examined whether CM3 delays gastric emptying (using the stable isotope 13 C‐octanoic breath test) and whether it influences subjective feelings of appetite sensations (using visual analog scales, VASs). We performed a double‐blind randomized placebo‐controlled crossover trial in 19 moderately obese but otherwise healthy subjects (mean age 55 ± 9 years, BMI 31.1 ± 4.6 kg/m 2 ). The subjects were treated with six capsules of CM3 or matching placebo 30 min before a standardized solid meal. Breath collection and VASs were performed over 4 h every 15 min and 30 min, respectively. Half‐excretion time of 13 CO 2 in breath, indicating gastric emptying half time, was the primary outcome parameter. The study was powered to detect a change in gastric emptying of 20–30 min. Mean 13 CO 2 half‐excretion time changed from 2.3 ± 0.4 to 2.4 ± 0.33 h (mean difference +6 min, 95% confidence interval (CI) −3 to +15 min; P = 0.17). Appetite sensations (hunger, satiation, fullness, prospective food consumption, desire to eat something sweet, salty, savory, or fatty) changed over time during the course of the postprandial phase but were not influenced by CM3 (repeated measures ANOVA). In obese subjects, acute administration of the weight‐loss supplement CM3 does not delay gastric emptying and does not influence subjective appetite sensations.