Premium
Contribution of the Lean Body Mass to Insulin Resistance in Postmenopausal Women With Visceral Obesity: A Monet Study
Author(s) -
Brochu Martin,
Mathieu MarieEve,
Karelis Antony D.,
Doucet Éric,
Lavoie MarieEve,
Garrel Dominique,
RabasaLhoret Rémi
Publication year - 2008
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2008.23
Subject(s) - medicine , endocrinology , insulin resistance , lean body mass , insulin , obesity , body fat distribution , homeostasis , glucose homeostasis , postmenopausal women , glucose clamp technique , pancreatic hormone , body weight
Some insulin‐resistant obese postmenopausal (PM) women are characterized by an android body fat distribution type and higher levels of lean body mass (LBM) compared to insulin‐sensitive obese PM women. This study investigates the independent contribution of LBM to the detrimental effect of visceral fat (VF) levels on the metabolic profile. One hundred and three PM women (age: 58.0 ± 4.9 years) were studied and categorized in four groups on the basis of their VF (higher vs. lower) and lean BMI (LBMI = LBM (kg)/height (m 2 ); higher vs. lower). Measures included: fasting lipids, glucose homeostasis (by euglycemic/hyperinsulinemic clamp technique and 2‐h oral glucose tolerance test (OGTT)), C‐reactive protein (CRP) levels, fat distribution (by computed tomography (CT) scan), and body composition (by dual‐energy X‐ray absorptiometry). Women in the higher VF/higher LBMI group had lower glucose disposal and higher plasma insulin levels compared to the other groups. They also had higher plasma CRP levels than the women in the lower VF/lower LBMI group. VF was independently associated with insulin levels, measures of glucose disposal, and CRP levels ( P < 0.05). LBMI was also independently associated with insulin levels, glucose disposal, and CRP levels ( P < 0.05). Finally, significant interactions were observed between LBMI and VF levels for insulin levels during the OGTT and measures of glucose disposal ( P < 0.05). In conclusion, VF and LBMI are both independently associated with alterations in glucose homeostasis and CRP levels. The contribution of VF to insulin resistance seems to be exacerbated by increased LBM in PM women.