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The Q121/Q121 Genotype of ENPP1/PC‐1 Is Associated with Lower BMI in Non‐diabetic Whites
Author(s) -
Prudente Sabrina,
Chandalia Manisha,
Morini Eleonora,
Baratta Roberto,
Dallapiccola Bruno,
Abate Nicola,
Frittitta Lucia,
Trischitta Vincenzo
Publication year - 2007
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2007.636
Subject(s) - obesity , medicine , genotype , body mass index , polymorphism (computer science) , diabetes mellitus , demography , statistical significance , endocrinology , gene , genetics , biology , sociology
This study investigated the role of the ENPP1/PC‐1 gene K121Q polymorphism in predicting BMI (kg/m 2 ) in non‐diabetic individuals. Three independent samples ( n = 631, n = 304, and n = 505) of adult whites were analyzed. Selection criteria were fasting plasma glucose level <126 mg/dL, absence of severe obesity (BMI ≥40 kg/m 2 ), and lack of treatment known to modulate BMI. In Sample 1, BMI values were different in individuals carrying the K121/K121 ( KK ), K121/Q121 ( KQ ), and Q121/Q121 ( QQ ) genotypes (25.5 ± 4.3, 25.3 ± 4.1, and 22.8 ± 2.5 kg/m 2 , respectively (adjusted p = 0.022); BMI values in Samples 2 and 3 also tended to be different, although the differences, after adjustment for age and sex, did not reach statistical significance. When data were pooled, BMI values were 25.8 ± 4.4, 25.6 ± 4.4, and 23.6 ± 3.3 kg/m 2 in KK, KQ, and QQ individuals (adjusted p = 0.029). According to a recessive model, QQ individuals had lower BMI values than KK and KQ individuals combined (23.6 ± 3.3 kg/m 2 vs. 25.7 ± 4.4 kg/m 2 ; adjusted p = 0.008). These data suggest that the QQ genotype of the ENPP1/PC‐1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity.