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Adiponectin Receptor 1 Variants Associated with Lower Insulin Resistance in African Americans
Author(s) -
Crimmins Nancy A.,
Woo Jessica G.,
Kaushal Ritesh D.,
Deka Ranjan,
Dolan Lawrence M.,
Martin Lisa J.
Publication year - 2007
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1038/oby.2007.225
Subject(s) - insulin resistance , single nucleotide polymorphism , adiponectin , haplotype , medicine , cohort , allele , endocrinology , waist , snp , biology , insulin , genetics , genotype , obesity , gene
Adiponectin has been shown to have a role in insulin resistance. However, little is known about the contribution of genetic variation in the adiponectin receptor 1 gene ( ADIPOR1 ) in this regard. We hypothesized that variation in ADIPOR1 would be associated with significant changes in insulin resistance and tested this hypothesis in a cohort of 483 African‐American adolescents. Seven single nucleotide polymorphisms (SNPs) of ADIPOR1 spanning from the promoter to the 3′‐untranslated region were genotyped. We analyzed single SNPs and haplotypes for associations with insulin resistance [homeostasis model assessment of insulin resistance (HOMA‐IR)] in the full cohort as well as lean (BMI < 85%) and non‐lean (BMI ≥ 85%) subsets. There was no evidence of ADIPOR1 variant effects on HOMA‐IR in the full cohort or in the lean subset. However, in the non‐lean subset, SNP +5843 ( A allele), and haplotypes including SNPs −8505/−5692/+3002/+5843 ( ATTA and AGTG ) showed significant associations with decreased HOMA‐IR after adjustment for sex, puberty, adiponectin, and waist z ‐score. Our findings suggest not only that ADIPOR1 variants influence insulin resistance in the presence of adiposity, but also that these variants and haplotypes are protective in African Americans.