Open AccessGender Differences in Lipoprotein Lipase Activity after Acute Exercise
Author(s) -
Perreault Leigh,
Lavely Jennifer M.,
Kittelson John M.,
Horton Tracy J.
Publication year - 2004
Publication title -
obesity research
Language(s) - English
Resource type - Journals
eISSN - 1550-8528
pISSN - 1071-7323
DOI - 10.1038/oby.2004.31
Subject(s) - adipose tissue , medicine , endocrinology , lipoprotein lipase , skeletal muscle , insulin , obesity
Abstract Objective : To determine whether gender differences exist in lipoprotein lipase (LPL) activity in response to exercise and/or insulin. Exercise and insulin are known modulators of LPL activity in men, but this is less clear in women. LPL activity may predict propensity for obesity; therefore, understanding its modulators is of considerable importance. Research Methods and Procedures : Gender differences in skeletal muscle and adipose tissue LPL activity were determined after a single bout of exercise followed by a hyperinsulinemic/euglycemic clamp and compared with an identical rest day in healthy lean men ( n = 10) and women ( n = 10). Muscle and adipose tissue biopsies were obtained pre‐ (post‐exercise vs. rest) and post‐clamp. Results : Basal levels of muscle and adipose tissue LPL activity were not different between men and women. There was, however, a significant gender by day interaction for muscle LPL activity ( p = 0.023) and adipose tissue LPL activity ( p = 0.013). In muscle, this was because of a significant increase in LPL activity on the exercise vs. rest day in men ( p < 0.001) but not women. Adipose tissue LPL activity also increased significantly in men on the exercise day relative to rest day ( p = 0.04) but decreased in women ( p = 0.10). The hyperinulinemic/euglycemic clamp had no independent effect on tissue LPL activity, in either gender, after rest or exercise. Discussion : In the 3 to 4 hours after exercise, muscle and adipose tissue LPL activity increased significantly in men, whereas LPL activity remained unchanged in women.