Open AccessPathophysiology and Long‐Term Management of the Metabolic Syndrome
Author(s) -
PiSunyer F. Xavier
Publication year - 2004
Publication title -
obesity research
Language(s) - English
Resource type - Journals
eISSN - 1550-8528
pISSN - 1071-7323
DOI - 10.1038/oby.2004.285
Subject(s) - medicine , metabolic syndrome , dyslipidemia , microalbuminuria , pharmacotherapy , disease , diabetes mellitus , obesity , type 2 diabetes , pathophysiology , intensive care medicine , bioinformatics , endocrinology , biology
The metabolic syndrome has been characterized by a cluster of abnormalities that include obesity, hyperglycemia, dyslipidemia, and hypertension. Other conditions associated with this syndrome include microalbuminuria, inflammation, a prothrombotic state, and a fatty liver. Together, these abnormalities lead to an environment where the risk of developing both type 2 diabetes and atherosclerotic cardiovascular disease are greatly enhanced. Recognition of this syndrome by practitioners, early treatment, and long‐term management are crucial for disease prevention. Successful treatment requires the introduction of lifestyle changes initially and pharmacotherapy subsequently if lifestyle changes are not sufficient.