Open AccessGender‐Specific Association of a Perilipin Gene Haplotype with Obesity Risk in a White Population
Author(s) -
Qi Lu,
Shen Haiqing,
Larson Ilona,
Schaefer Ernst J.,
Greenberg Andrew S.,
Tregouet David A.,
Corella Dolores,
Ordovas Jose M.
Publication year - 2004
Publication title -
obesity research
Language(s) - English
Resource type - Journals
eISSN - 1550-8528
pISSN - 1071-7323
DOI - 10.1038/oby.2004.218
Subject(s) - perilipin , haplotype , odds ratio , single nucleotide polymorphism , obesity , medicine , waist , confidence interval , genetics , endocrinology , allele , biology , genotype , adipose tissue , gene , lipolysis
Objective : Perilipin is a class of protein‐coating lipid droplets in adipocytes and steroidogenic cells. Our purpose was to examine the association between common single‐nucleotide polymorphisms (SNPs) at the perilipin ( PLIN ) locus and obesity, as well as related phenotypes, in unrelated American adults. Research Methods and Procedures : Four PLIN SNPs ( PLIN 6209T>C, 11482G>A, 13041A>G, and 14995A>T) were typed in 734 white subjects (373 men and 361 women) attending a residential lifestyle intervention program. The baseline anthropometric and biochemical measures were used. Obesity was defined as BMI ≥ 30 kg/m 2 . Results : Multivariate analysis demonstrated that, in women, two of the SNPs (13041A>G, and 14995A>T) were significantly associated with percentage body fat ( p = 0.016 for 13041A>G and p = 0.010 for 14995A>T) and waist circumference ( p = 0.020 for 13041A>G and p = 0.045 for 14995A>T). Moreover, haplotype analysis using these two SNPs indicated that haplotypes A/T and G/T were both associated with significantly increased obesity risk (odds ratio = 1.76, 95% confidence interval 1.07 to 2.90 for haplotype A/T, and odds ratio = 1.73, 95% confidence interval 1.06 to 2.82 for haplotype G/T) when compared with haplotype A/A. No significant associations between PLIN variations and obesity were found in men. Discussion : Our data support the hypothesis that the PLIN locus may be a significant genetic determinant for obesity risk in whites and that women are more sensitive to the genetic effects of perilipin than men.