Open AccessVisceral Adipose Tissue and Markers of the Insulin Resistance Syndrome in Obese Black and White Teenagers
Author(s) -
Owens Scott,
Gutin Bernard,
Barbeau Paule,
Litaker Mark,
Allison Jerry,
Humphries Matthew,
Okuyama Tomoki,
Le NgocAnh
Publication year - 2000
Publication title -
obesity research
Language(s) - English
Resource type - Journals
eISSN - 1550-8528
pISSN - 1071-7323
DOI - 10.1038/oby.2000.34
Subject(s) - medicine , endocrinology , insulin resistance , adipose tissue , blood pressure , cholesterol , obesity , lipoprotein , high density lipoprotein , insulin , blood lipids
Objective: To determine the relationships between visceral and general adiposity, cardiovascular fitness, and markers of the insulin resistance syndrome in obese black and white teenagers. Research Methods and Procedures: Cross‐sectional survey of 81 obese 13‐ to 16‐year‐old youths. Visceral adipose tissue was measured with magnetic resonance imaging, and percentage body fat was measured with dual‐energy X‐ray absorptiometry. Cardiovascular fitness was assessed with a submaximal treadmill test. Fasting blood samples were analyzed for lipids/lipoproteins and insulin. Resting blood pressure was obtained using an automated cuff. Results: Visceral adipose tissue was significantly correlated with unfavorable levels of: triacylglycerol ( r = 0.27, p < 0.05), total cholesterol ( r = 0.27, p < 0.05), high‐density lipoprotein cholesterol ( r = −0.26, p < 0.05), the ratio of total cholesterol/high‐density lipoprotein cholesterol ( r = 0.42, p < 0.01), low‐density lipoprotein cholesterol ( r = 0.27, p < 0.05), apolipoprotein B ( r = 0.38, p < 0.01), and systolic blood pressure ( r = 0.30, p < 0.01). Multiple regression analyses revealed that visceral adipose tissue was more powerful than percentage body fat for explaining variance in lipoproteins (e.g., for the ratio of total cholesterol/high‐density lipoprotein cholesterol, r 2 = 0.13, p < 0.01, and for systolic blood pressure, r 2 = 0.07, p < 0.05). Ethnicity was the most powerful of the demographic predictors for blood lipids ( r 2 = 0.15 for triacylglycerol with lower levels in blacks; r 2 = 0.10 for high‐density lipoprotein cholesterol with higher levels in blacks; r 2 = 0.06 for the ratio of total cholesterol/high‐density lipoprotein cholesterol with lower levels in blacks). Cardiovascular fitness was not retained as a significant predictor of markers of the insulin resistance syndrome. Discussion: Some of the deleterious relationships between visceral adiposity and markers for the insulin resistance syndrome seen in adults were already present in these obese young people.