Open AccessCrescentic glomerulonephritis: beyond the immune system
Author(s) -
Philip Webster,
Charles D. Pusey
Publication year - 2017
Publication title -
nature reviews nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.606
H-Index - 111
eISSN - 1759-507X
pISSN - 1759-5061
DOI - 10.1038/nrneph.2017.32
Subject(s) - glomerulonephritis , medicine , immune system , immunology , cytokine , kidney
T cells mediate injury in glomerulonephritis but mice devoid of T cells and B cells can also develop this disease. A new study shows that expression of the cytokine receptor common subunit γ and IL-15 in podocytes protects against crescentic glomerulonephritis, independent of B cells, T cells and natural killer cells
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