Merging functional studies with structures of inward-rectifier K+ channels | Zendy

Delphine Bichet | Zendy; Friederike A. Haass | Zendy; Lily Yeh Jan | Zendy

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Merging functional studies with structures of inward-rectifier K+ channels

Author(s) -

Delphine Bichet,

Friederike A. Haass,

Lily Yeh Jan

Publication year - 2003

Publication title -

nature reviews. neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 11.585

H-Index - 413

eISSN - 1471-0048

pISSN - 1471-003X

DOI - 10.1038/nrn1244

Subject(s) - inward rectifier potassium ion channel , gating , rectification , neuroscience , potassium channel , ion channel , intracellular , biophysics , chemistry , biology , microbiology and biotechnology , biochemistry , engineering , receptor , voltage , electrical engineering

Inwardly rectifying K(+) (Kir) channels have a wide range of functions including the control of neuronal signalling, heart rate, blood flow and insulin release. Because of the physiological importance of these channels, considerable effort has been invested in understanding the structural basis of their physiology. In this review, we use two recent, high-resolution structures as foundations for examining our current understanding of the fundamental functions that are shared by all K(+) channels, such as K(+) selectivity and channel gating, as well as characteristic features of Kir channel family members, such as inward rectification and their regulation by intracellular factors.

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