Signaling Flux Redistribution concept can switch survival to apoptosis in cancer cells | Zendy

Daiki Yamada | Zendy; Kentaro Hayashi | Zendy; Vincent Piras | Zendy; Masaru Tomita | Zendy; Masa Tsuchiya | Zendy; Kumar Selvarajoo | Zendy

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Signaling Flux Redistribution concept can switch survival to apoptosis in cancer cells

Author(s) -

Daiki Yamada,

Kentaro Hayashi,

Vincent Piras,

Masaru Tomita,

Masa Tsuchiya,

Kumar Selvarajoo

Publication year - 2010

Publication title -

nature precedings

Language(s) - English

Resource type - Journals

ISSN - 1756-0357

DOI - 10.1038/npre.2010.4375.1

Subject(s) - apoptosis , in silico , fibrosarcoma , microbiology and biotechnology , cancer research , chemistry , biology , genetics , biochemistry , gene

The tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis in certain types of carcinoma. However, in majority of malignant tumors, it has no effect. Here we analyzed cell survival and apoptotic pathways triggered by TRAIL. A computational model based on perturbation-response approach with mass-action equations was developed. All 48 parameter values of the model were selected by genetic algorithm that minimizes deviation between experimental and simulation data for human fibrosarcoma cells. Subsequently, we show in silico knock-down of a cell survival pathway molecule could potentially enhance the activation of apoptosis through Signaling Flux Redistribution (SFR)

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