Open AccessReciprocal homeostatic reactions to chronic excitatory synaptic receptor inactivation in developing cerebral cortex networks
Author(s) -
M.A. Corner
Publication year - 2007
Publication title -
nature precedings
Language(s) - English
Resource type - Journals
ISSN - 1756-0357
DOI - 10.1038/npre.2007.1260.3
Subject(s) - neuroscience , excitatory postsynaptic potential , homeostasis , cerebral cortex , homeostatic plasticity , chemistry , reciprocal , neurotransmission , receptor , metaplasticity , biology , inhibitory postsynaptic potential , endocrinology , biochemistry , linguistics , philosophy
Chronic blockade of actively excitatory glutamatergic synaptic receptors in co-cultured organotypic rodent neocortex explants leads to a compensatory up-regulation of otherwise inactive input channels so as to maintain almost normal levels of ongoing bursts of action potentials. We report here that this homeostatic return of spontaneous (now kainate receptor driven) firing is accompanied by a reciprocal down-regulation of blocked AMPA and NMDA receptors, such that the developing cortical network is protected against becoming hyperactive when those synaptic inputs are again able to transmit normally