Open AccessAbnormal hippocampal–thalamic white matter tract development and positive symptom course in individuals at ultra-high risk for psychosis
Author(s) -
Bernard Ja,
Joseph M. Orr,
Vijay A. Mittal
Publication year - 2015
Publication title -
npj schizophrenia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.173
H-Index - 23
ISSN - 2334-265X
DOI - 10.1038/npjschz.2015.9
Subject(s) - white matter , fractional anisotropy , psychosis , diffusion mri , hippocampal formation , hippocampus , thalamus , psychology , schizophrenia (object oriented programming) , tractography , medicine , neuroscience , magnetic resonance imaging , psychiatry , radiology
Abnormal development of the hippocampus has been reported in adolescents at ultra-high risk (UHR) for psychosis and thalamic abnormalities have been found. However, the white matter connections between the hippocampus and the thalamus have not been studied. The connections between these regions are of key importance to our understanding of the pathophysiology of psychosis.