Open AccessAdiponectin/adiponectin receptor in disease and aging
Author(s) -
Masato Iwabu,
Miki Okada-Iwabu,
Toshimasa Yamauchi,
Takashi Kadowaki
Publication year - 2015
Publication title -
npj aging and mechanisms of disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 19
ISSN - 2056-3973
DOI - 10.1038/npjamd.2015.13
Subject(s) - adiponectin , adipokine , adiponectin receptor 1 , type 2 diabetes , endocrinology , medicine , diabetes mellitus , receptor , disease , endocrine system , metabolic syndrome , biology , insulin resistance , hormone
Adipocytes are not merely organs for energy conservation but endocrine organs secreting a wide array of physiologically active substances, i.e., adipokines. Of these adipokines, adiponectin is known to exert anti-diabetic and anti-atherosclerotic effects via adiponectin receptors (AdipoR)s, AdipoR1 and AdipoR2. Adiponectin has also recently been shown to regulate longevity signaling thus prolonging lifespan. Therefore, the strategy for activating adiponectin/AdipoR signaling pathways are expected to provide a solid basis for the prevention and treatment of obesity-related diseases such as the metabolic syndrome, type 2 diabetes and cardiovascular disease, as well as for ensuring healthy longevity in humans.