Conformational landscape of a virus by single-particle X-ray scattering | Zendy

Ahmad Hosseinizadeh | Zendy; Ghoncheh Mashayekhi | Zendy; Jeremy Copperman | Zendy; Peter Schwander | Zendy; Ali Dashti | Zendy; Reyhaneh Sepehr | Zendy; Russell Fung | Zendy; Marius Schmidt | Zendy; Chun Hong Yoon | Zendy; Brenda G. Hogue | Zendy; Garth J. Williams | Zendy; Andrew Aquila | Zendy; A. Ourmazd | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Conformational landscape of a virus by single-particle X-ray scattering

Author(s) -

Ahmad Hosseinizadeh,

Ghoncheh Mashayekhi,

Jeremy Copperman,

Peter Schwander,

Ali Dashti,

Reyhaneh Sepehr,

Russell Fung,

Marius Schmidt,

Chun Hong Yoon,

Brenda G. Hogue,

Garth J. Williams,

Andrew Aquila,

A. Ourmazd

Publication year - 2017

Publication title -

nature methods

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.469

H-Index - 318

eISSN - 1548-7105

pISSN - 1548-7091

DOI - 10.1038/nmeth.4395

Subject(s) - resolution (logic) , scattering , genome , particle (ecology) , crystallography , physics , biophysics , optics , chemistry , biology , gene , computer science , biochemistry , artificial intelligence , ecology

Using a manifold-based analysis of experimental diffraction snapshots from an X-ray free electron laser, we determine the three-dimensional structure and conformational landscape of the PR772 virus to a detector-limited resolution of 9 nm. Our results indicate that a single conformational coordinate controls reorganization of the genome, growth of a tubular structure from a portal vertex and release of the genome. These results demonstrate that single-particle X-ray scattering has the potential to shed light on key biological processes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research