Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema | Zendy

Nicolai Ε. Savaskan | Zendy; Alexandra Heckel | Zendy; Eric Hahnen | Zendy; Tobias Engelhorn | Zendy; Arnd Doerfler | Zendy; Oliver Ganslandt | Zendy; Christopher Nimsky | Zendy; Michael Buchfelder | Zendy; Ilker Y. Eyüpoglu | Zendy

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Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

Author(s) -

Nicolai Ε. Savaskan,

Alexandra Heckel,

Eric Hahnen,

Tobias Engelhorn,

Arnd Doerfler,

Oliver Ganslandt,

Christopher Nimsky,

Michael Buchfelder,

Ilker Y. Eyüpoglu

Publication year - 2008

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm1772

Subject(s) - neurodegeneration , gene silencing , small interfering rna , glioma , glutamate receptor , edema , neuroscience , programmed cell death , brain edema , biology , medicine , pathology , cancer research , rna , apoptosis , gene , biochemistry , receptor , disease

Neurodegeneration and brain edema are hallmarks of human malignant brain tumors. Here we show that genetic or pharmacological inhibition of the glutamate transporter xCT (X(c-) system, encoded by SLC7a11) in vivo leads to abrogated neurodegeneration, attenuated perifocal edema and prolonged survival. These results show a crucial role for xCT in glioma-induced neurodegeneration and brain edema, corroborating the concept that edema formation may be in part a consequence of peritumoral cell death.

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