Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation | Zendy

Jiayi Li | Zendy; Elisabet Englund | Zendy; Janice L. Holton | Zendy; Denis Soulet | Zendy; Peter Hagell | Zendy; Andrew J. Lees | Zendy; Tammaryn Lashley | Zendy; Niall Quinn | Zendy; Stig Rehncrona | Zendy; Anders Björklund | Zendy; Håkan Widner | Zendy; Tamás Révész | Zendy; Olle Lindvall | Zendy; Patrik Brundin | Zendy

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

Author(s) -

Jiayi Li,

Elisabet Englund,

Janice L. Holton,

Denis Soulet,

Peter Hagell,

Andrew J. Lees,

Tammaryn Lashley,

Niall Quinn,

Stig Rehncrona,

Anders Björklund,

Håkan Widner,

Tamás Révész,

Olle Lindvall,

Patrik Brundin

Publication year - 2008

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm1746

Subject(s) - parkinson's disease , disease , pathogenesis , dopaminergic , alpha synuclein , neuroscience , substantia nigra , medicine , pathology , biology , dopamine

Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

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