A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines | Zendy

Amin E. Moghaddam | Zendy; Wieslawa Olszewska | Zendy; Belinda Wang | Zendy; John S. Tregoning | Zendy; Rebecca Helson | Zendy; Quentin J. Sattentau | Zendy; Peter Openshaw | Zendy

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A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines

Author(s) -

Amin E. Moghaddam,

Wieslawa Olszewska,

Belinda Wang,

John S. Tregoning,

Rebecca Helson,

Quentin J. Sattentau,

Peter Openshaw

Publication year - 2006

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm1456

Subject(s) - antigen , formaldehyde , respiratory system , immunology , chemistry , virology , medicine , biochemistry

Heat, oxidation and exposure to aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors. Formaldehyde is widely used in making vaccines, but has been associated with atypical enhanced disease during subsequent infection with paramyxoviruses. We show that carbonyl groups on formaldehyde-treated vaccine antigens boost T helper type 2 (T(H)2) responses and enhance respiratory syncytial virus (RSV) disease in mice, an effect partially reversible by chemical reduction of carbonyl groups.

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