Open AccessThe T-ALL paradox in cancer
Author(s) -
Trang Hoang,
Thu Hoàng
Publication year - 2010
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm1110-1185
Subject(s) - homeobox , suppressor , biology , cancer research , leukemia , gene , cancer , genetics , gene expression
International audienceOverexpression of T cell leukemia homeobox 1 (TLX1) occurs in some leukemias. New findings in mice and humans show how TLX1 drives chromosomal aberrations and deletions of tumor suppressor genes during T-cell transformation (pages 13211327). Surprisingly, its expression does not correlate with bad prognosis
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