Open AccessKeeping blood clots at bay in sepsis
Author(s) -
Cornelis van ‘t Veer,
Tom van der Poll
Publication year - 2008
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm0608-606
Subject(s) - sepsis , platelet , coagulation , glycoprotein , immunology , platelet membrane glycoprotein , receptor , medicine , bacteremia , chemistry , biology , microbiology and biotechnology , biochemistry , antibiotics
Clearance of platelets by the liver can help counteract the dangerous blood coagulation that can occur during sepsis. The mechanism involves clearance of platelets through the liver's Ashwell receptor, which binds to platelet glycoproteins altered by sepsis-causing bacteria (pages 648-655
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