The saving switch | Zendy

Cassandra Willyard | Zendy

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The saving switch

Author(s) -

Cassandra Willyard

Publication year - 2010

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm0110-18

Subject(s) - epigenome , epigenetics , computational biology , dna , gene , disease , biology , dna methylation , genetics , computer science , medicine , gene expression , pathology

The epigenome consists of a system of chemical tags that attach to our DNA and its associated molecules, switching genes on and off. But the system is not without glitches-and scientists think that the misplacement of these tags can cause disease. This idea has led to new drugs that aim to correct gene activity (and obliterate disease) by altering the proteins around which DNA winds. Cassandra Willyard examines whether this approach will unlock the long-awaited promise of epigenetic therapy.

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