Open AccessMicroRNA-124 modulates social behavior in frontotemporal dementia
Author(s) -
Andrew E. Arrant,
Erik D. Roberson
Publication year - 2014
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.3768
Subject(s) - frontotemporal dementia , microrna , neuroscience , dementia , prefrontal cortex , disease , frontotemporal lobar degeneration , semantic dementia , glutamate receptor , psychology , medicine , receptor , biology , genetics , cognition , gene
Frontotemporal dementia (FTD) is a neurodegenerative disease that causes social dysfunction and other symptoms. A new study suggests that social dysfunction in FTD is due to decreased microRNA-124 expression and resulting changes in glutamate receptor composition in the prefrontal cortex.
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