Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge | Zendy

Daphne A. Stanley | Zendy; An. Honko | Zendy; Clement Asiedu | Zendy; John C. Trefry | Zendy; Annie W. Lau-Kilby | Zendy; Joshua C. Johnson | Zendy; Lisa E. Hensley | Zendy; Virginia Ammendola | Zendy; Adele Abbate | Zendy; Fabiana Grazioli | Zendy; Kathryn E. Foulds | Zendy; Cheng Cheng | Zendy; Lingshu Wang | Zendy; Mitzi M. Donaldson | Zendy; Stefano Colloca | Zendy; Antonella Folgori | Zendy; Mario Roederer | Zendy; Gary J. Nabel | Zendy; John R. Mascola | Zendy; Alfredo Nicosia | Zendy; Riccardo Cortese | Zendy; Richard A. Koup | Zendy; Nancy J. Sullivan | Zendy

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Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge

Author(s) -

Daphne A. Stanley,

An. Honko,

Clement Asiedu,

John C. Trefry,

Annie W. Lau-Kilby,

Joshua C. Johnson,

Lisa E. Hensley,

Virginia Ammendola,

Adele Abbate,

Fabiana Grazioli,

Kathryn E. Foulds,

Cheng Cheng,

Lingshu Wang,

Mitzi M. Donaldson,

Stefano Colloca,

Antonella Folgori,

Mario Roederer,

Gary J. Nabel,

John R. Mascola,

Alfredo Nicosia,

Riccardo Cortese,

Richard A. Koup,

Nancy J. Sullivan

Publication year - 2014

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.3702

Subject(s) - ebolavirus , virology , modified vaccinia ankara , immunity , biology , vaccinia , vaccination , outbreak , immunology , ebola vaccine , ebola virus , immune system , genetics , gene , recombinant dna

Ebolavirus disease causes high mortality, and the current outbreak has spread unabated through West Africa. Human adenovirus type 5 vectors (rAd5) encoding ebolavirus glycoprotein (GP) generate protective immunity against acute lethal Zaire ebolavirus (EBOV) challenge in macaques, but fail to protect animals immune to Ad5, suggesting natural Ad5 exposure may limit vaccine efficacy in humans. Here we show that a chimpanzee-derived replication-defective adenovirus (ChAd) vaccine also rapidly induced uniform protection against acute lethal EBOV challenge in macaques. Because protection waned over several months, we boosted ChAd3 with modified vaccinia Ankara (MVA) and generated, for the first time, durable protection against lethal EBOV challenge.

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