Open AccessInhibiting Janus kinases to treat alopecia areata
Author(s) -
Sherrie J. Divito,
Thomas S. Kupper
Publication year - 2014
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.3685
Subject(s) - alopecia areata , janus kinase , kinase , nkg2d , hair loss , medicine , dermatology , cancer research , immunology , biology , microbiology and biotechnology , genetics , cytotoxic t cell , in vitro
Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ⁺NKG2D⁺ T effector memory cells mediate alopecia areata in part through Janus kinase (JAK) signaling and that alopecia areata might be treated with JAK inhibitors.
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