Open AccessNeuregulin-1 alleviates Charcot-Marie-Tooth disease in rats
Author(s) -
Rudolf Martini
Publication year - 2014
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.3684
Subject(s) - neuregulin 1 , neuregulin , schwann cell , tooth disease , neuroscience , medicine , disease , biology , pathology , microbiology and biotechnology , signal transduction
Disrupted differentiation of Schwann cells contributes to axonal loss in a rat model of Charcot-Marie-Tooth 1A neuropathy. Early neuregulin-1 treatment promotes Schwann cell differentiation, preserves axons and restores nerve function in this model.
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