Open AccessA new activity for SAMHD1 in HIV restriction
Author(s) -
Zhiyuan Yang,
Warner C. Greene
Publication year - 2014
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.3657
Subject(s) - samhd1 , human immunodeficiency virus (hiv) , virology , biology , mutant , rna , reverse transcriptase , genetics , gene
Restriction factors are host cell proteins that inhibit retroviral infection. A new study using mutants of human HIV-1 restriction factor SAMHD1 suggests that it inhibits infection through degradation of viral RNA rather than through its dNTPase activity as previously suggested.
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