Open AccessAkt2 relaxes podocytes in chronic kidney disease
Author(s) -
Jochen Reiser
Publication year - 2013
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.3357
Subject(s) - kidney disease , disease , proteinuria , sirolimus , medicine , akt2 , kidney , podocyte , cancer research , biology , signal transduction , microbiology and biotechnology , akt1 , pi3k/akt/mtor pathway
A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1288–1296).
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