Forever (FGF) 21 | Zendy

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Forever (FGF) 21

Author(s) -

Joseph Bass

Publication year - 2013

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.3334

Subject(s) - fgf21 , fibroblast growth factor , klotho , starvation , microbiology and biotechnology , biology , longevity , reproduction , circadian clock , endocrinology , circadian rhythm , intermittent fasting , fibroblast growth factor receptor , medicine , signal transduction , adaptation (eye) , neuroscience , receptor , genetics , kidney

The fibroblast growth factor 21 (FGF21)-β-Klotho pathway orchestrates a switch to oxidative metabolism during fasting and starvation and has been implicated as a signal connecting nutrition, growth, reproduction and longevity. Two new studies in mice show that Fgf21 interacts directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting.

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