Open AccessAlzheimer's and prion diseases: PDK1 at the crossroads
Author(s) -
Frédéric Checler
Publication year - 2013
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.3332
Subject(s) - neuroscience , medicine , computational biology , biology , virology
TACE-mediated proteolysis is a key event interfering with both Alzheimer's and prion diseases. A new study shows that phosphoinositide-dependent kinase-1 (PDK1) is activated by cellular prion protein, which alters membrane-associated TACE levels, thereby influencing both Alzheimer's and prion pathologies.
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