Open AccessObesity Notches up fatty liver
Author(s) -
Michael P. Czech
Publication year - 2013
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.3293
Subject(s) - lipogenesis , obesity , fatty liver , regulator , type 2 diabetes , endocrinology , medicine , biology , diabetes mellitus , adipose tissue , disease , biochemistry , gene
Pathologic fatty liver paradoxically accompanies obesity and type 2 diabetes despite the crippling of insulin signaling, which is normally required for fat synthesis. The developmental signaling protein Notch is a hidden regulator of lipogenesis that amplifies signal transmissions to fat production in these metabolic diseases
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