Open AccessIon channels boost axonal injury in multiple sclerosis
Author(s) -
Reinhard Hohlfeld
Publication year - 2012
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.3021
Subject(s) - multiple sclerosis , neurodegeneration , transient receptor potential channel , ion channel , neuroscience , medicine , receptor , biology , chemistry , pathology , immunology , disease
In neuroinflammatory diseases such as multiple sclerosis, ion channels may fan the embers of neurodegeneration. A new study shows that the cation channel TRPM4 (transient receptor potential melastatin 4) crucially contributes to axonal loss in an animal model of multiple sclerosis (pages 1805-1811)
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