Open AccessWaking up HSCs: a new role for E-selectin
Author(s) -
Malcolm A.S. Moore
Publication year - 2012
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.2992
Subject(s) - haematopoiesis , stem cell , bone marrow , niche , e selectin , microbiology and biotechnology , biology , cell adhesion molecule , endothelial stem cell , function (biology) , cell adhesion , immunology , cell , genetics , in vitro , biochemistry
Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone marrow, but a distinct function for each of these niches has remained unclear. A new role in stem cell proliferation has now been identified for the adhesion molecule E-selectin expressed by bone marrow endothelial cells at the vascular niche (pages 1651-1657).
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