Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers | Zendy

Bérengère Fromy | Zendy; Éric Lingueglia | Zendy; Dominique SigaudoRoussel | Zendy; J. L. Saumet | Zendy; Michel Lazdunski | Zendy

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Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers

Author(s) -

Bérengère Fromy,

Éric Lingueglia,

Dominique SigaudoRoussel,

J. L. Saumet,

Michel Lazdunski

Publication year - 2012

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.2844

Subject(s) - vasodilation , vasomotor , medicine , trpv4 , pressure sensitive , chemistry , cardiology , ion channel , receptor , adhesive , organic chemistry , layer (electronics)

Pressure-induced vasodilation (PIV) delays the decrease in cutaneous blood flow produced by local application of low pressure to the skin, a physiologically appropriate adjustment of local vasomotor function. Individuals without a normal PIV response have a high risk of ulceration. Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and for protecting against pressure ulcers in mice.

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