King of hearts: a splicing factor rules cardiac proteins | Zendy

Wolfgang A. Linke | Zendy; Sandra Bücker | Zendy

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King of hearts: a splicing factor rules cardiac proteins

Author(s) -

Wolfgang A. Linke,

Sandra Bücker

Publication year - 2012

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.2762

Subject(s) - rna splicing , splicing factor , alternative splicing , gene isoform , splice , biology , gene , genetics , cardiomyopathy , mutation , heart failure , computational biology , microbiology and biotechnology , bioinformatics , medicine , rna

Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766-773).

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