Re-establishing immunological self-tolerance in autoimmune disease | Zendy

Shimon Sakaguchi | Zendy; Fiona Powrie | Zendy; Richard M. Ransohoff | Zendy

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Re-establishing immunological self-tolerance in autoimmune disease

Author(s) -

Shimon Sakaguchi,

Fiona Powrie,

Richard M. Ransohoff

Publication year - 2012

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.2622

Subject(s) - self tolerance , peripheral tolerance , immunology , autoimmune disease , immune system , disease , immune tolerance , effector , autoimmunity , clonal deletion , biology , medicine , t cell , antibody , t cell receptor , pathology

Recent progress has revealed the molecular basis of how self-reactive T cells are normally generated in the immune system and differentiate into autoimmune effector T cells and how they are controlled by central and peripheral mechanisms of self-tolerance. There is also evidence that target tissues and cells in autoimmune disease have different sensitivities to immune mediators. Here we describe how these basic findings can be clinically translated to re-establish self-tolerance in individuals with autoimmune disease. © 2012 Nature America, Inc. All rights reserved

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