A pharmacological approach to first aid treatment for snakebite | Zendy

Megan Saul | Zendy; Paul Thomas | Zendy; Peter J. Dosen | Zendy; Geoffrey K. Isbister | Zendy; Margaret A. O’Leary | Zendy; Ian M. Whyte | Zendy; Sally A. McFadden | Zendy; Dirk van Helden | Zendy

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A pharmacological approach to first aid treatment for snakebite

Author(s) -

Megan Saul,

Paul Thomas,

Peter J. Dosen,

Geoffrey K. Isbister,

Margaret A. O’Leary,

Ian M. Whyte,

Sally A. McFadden,

Dirk van Helden

Publication year - 2011

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.2382

Subject(s) - antivenom , lymphatic system , medicine , lymph , nitric oxide , venom , medical care , pharmacology , anesthesia , intensive care medicine , immunology , pathology , emergency medicine , biology , ecology

Snake venom toxins first transit the lymphatic system before entering the bloodstream. Ointment containing a nitric oxide donor, which impedes the intrinsic lymphatic pump, prolonged lymph transit time in rats and humans and also increased rat survival time after injection of venom. This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment.

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