Cancer genomics: from discovery science to personalized medicine | Zendy

Lynda Chin | Zendy; Jannik N. Andersen | Zendy; P. Andrew Futreal | Zendy

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Cancer genomics: from discovery science to personalized medicine

Author(s) -

Lynda Chin,

Jannik N. Andersen,

P. Andrew Futreal

Publication year - 2011

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.2323

Subject(s) - personalized medicine , genomics , precision medicine , bench to bedside , cancer medicine , computational biology , cancer , scientific discovery , genome , data science , bioinformatics , computer science , medicine , biology , genetics , medical physics , psychology , pathology , gene , cognitive science

Recent advances in genome technologies and the ensuing outpouring of genomic information related to cancer have accelerated the convergence of discovery science and clinical medicine. Successful examples of translating cancer genomics into therapeutics and diagnostics reinforce its potential to make possible personalized cancer medicine. However, the bottlenecks along the path of converting a genome discovery into a tangible clinical endpoint are numerous and formidable. In this Perspective, we emphasize the importance of establishing the biological relevance of a cancer genomic discovery in realizing its clinical potential and discuss some of the major obstacles to moving from the bench to the bedside.

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