Open AccessThe cancer stem cell: premises, promises and challenges
Author(s) -
Hans Clevers
Publication year - 2011
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.2304
Subject(s) - premises , stem cell , cancer , engineering ethics , biology , political science , law , engineering , genetics
Over the last decade, the notion that tumors are maintained by their own stem cells, the so-called cancer stem cells, has created great excitement in the research community. This review attempts to summarize the underlying concepts of this notion, to distinguish hard facts from beliefs and to define the future challenges of the field.
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