Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects | Zendy

Pei Lin | Zendy; Shupeng Li | Zendy; Min Wang | Zendy; Mustansir Diwan | Zendy; Hymie Anisman | Zendy; Paul Fletcher | Zendy; José N. Nóbrega | Zendy; Fang Liu | Zendy

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Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects

Author(s) -

Pei Lin,

Shupeng Li,

Min Wang,

Mustansir Diwan,

Hymie Anisman,

Paul Fletcher,

José N. Nóbrega,

Fang Liu

Publication year - 2010

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.2263

Subject(s) - dopamine , learned helplessness , dopamine receptor d2 , antidepressant , behavioural despair test , receptor , neurotransmitter , dopamine receptor , neurotransmitter receptor , dopamine receptor d1 , neuroscience , psychology , medicine , endocrinology , pharmacology , biology , developmental psychology , hippocampus

We report that coupling between dopamine D1 and D2 receptors was markedly increased in postmortem brain of subjects suffering from major depression. Biochemical analyses revealed that D1 and D2 receptors form heterodimers via a direct protein-protein interaction. Administration of an interfering peptide that disrupts the D1-D2 receptor complex substantially reduced immobility in the forced swim test (FST) without affecting locomotor activity, and decreased escape failures in learned helplessness tests in rats.

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