Open AccessBiomarkers in Alzheimer's disease drug development
Author(s) -
Kaj Blennow
Publication year - 2010
Publication title -
nature medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.536
H-Index - 547
eISSN - 1546-170X
pISSN - 1078-8956
DOI - 10.1038/nm.2221
Subject(s) - drug development , disease , drug , drug trial , medicine , clinical trial , efficacy , biomarker , drug discovery , bioinformatics , pharmacology , biology , biochemistry
Biomarkers may be of great value in Alzheimer's disease drug development to select the most optimal drug candidates for large and expensive phase 3 clinical trials. Biomarkers will also be important to provide evidence that a drug affects the underlying pathophysiology of the disease, which, together with a beneficial effect on the clinical course, will be essential for labeling the drug as having a disease-modifying effect.
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