Advanced antisense therapies for postexposure protection against lethal filovirus infections | Zendy

Travis K. Warren | Zendy; Kelly L. Warfield | Zendy; Jay Wells | Zendy; Dana L. Swenson | Zendy; Kelly S Donner | Zendy; Sean A. Van Tongeren | Zendy; Nicole L. Garza | Zendy; Dong Liu | Zendy; Dan V. Mourich | Zendy; Stacy Crumley | Zendy; Donald K. Nichols | Zendy; Patrick L. Iversen | Zendy; Sina Bavari | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Advanced antisense therapies for postexposure protection against lethal filovirus infections

Author(s) -

Travis K. Warren,

Kelly L. Warfield,

Jay Wells,

Dana L. Swenson,

Kelly S Donner,

Sean A. Van Tongeren,

Nicole L. Garza,

Dong Liu,

Dan V. Mourich,

Stacy Crumley,

Donald K. Nichols,

Patrick L. Iversen,

Sina Bavari

Publication year - 2010

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.2202

Subject(s) - marburg virus , ebola virus , virology , ebolavirus , viral hemorrhagic fever , medicine , virus , biology , immunology

Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show that administration of positively charged phosphorodiamidate morpholino oligomers (PMOplus), delivered by various dosing strategies initiated 30-60 min after infection, protects>60% of rhesus monkeys against lethal Zaire Ebola virus (ZEBOV) and 100% of cynomolgus monkeys against Lake Victoria Marburg virus (MARV) infection. PMOplus may be useful for treating these and other highly pathogenic viruses in humans.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research