Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy | Zendy

Magdalena Filipowicz Sinnreich | Zendy; Jacek Król | Zendy; Ilona Markiewicz | Zendy; Markus H. Heim | Zendy; Witold Filipowicz | Zendy

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Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy

Author(s) -

Magdalena Filipowicz Sinnreich,

Jacek Król,

Ilona Markiewicz,

Markus H. Heim,

Witold Filipowicz

Publication year - 2009

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.1902

Subject(s) - microrna , interferon , mir 122 , hepatitis c virus , immunology , hepatitis c , medicine , virology , viral load , viral replication , virus , biology , gene , genetics

Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Our analysis of liver biopsies from subjects with chronic hepatitis C (CHC) undergoing IFN therapy revealed no correlation of miR-122 expression with viral load and markedly decreased pretreatment miR-122 levels in subjects who had no virological response during later IFN therapy; other investigated miRNAs showed only limited changes. These data have implications for the prospect of targeting miRNAs for CHC therapy.

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