PlGF–MMP-9–expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle | Zendy

Cesare Gargioli | Zendy; M. Coletta | Zendy; Fabrizio De Grandis | Zendy; Stefano Cannata | Zendy; Giulio Cossu | Zendy

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PlGF–MMP-9–expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle

Author(s) -

Cesare Gargioli,

M. Coletta,

Fabrizio De Grandis,

Stefano Cannata,

Giulio Cossu

Publication year - 2008

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.1852

Subject(s) - microcirculation , medicine , matrix metalloproteinase , cell therapy , muscular dystrophy , cell , microbiology and biotechnology , biology , endocrinology , biochemistry

Sclerosis and reduced microvessel density characterize advanced stages of muscular dystrophy and hamper cell or gene delivery, precluding treatment of most individuals with Duchenne muscular dystrophy. Modified tendon fibroblasts expressing an angiogenic factor (placenta growth factor, PlGF) and a metalloproteinase (matrix metalloproteinase-9, MMP-9) are able to restore a vascular network and reduce collagen deposition, allowing efficient cell therapy in aged dystrophic mice. These data open the possibility of extending new therapies to currently untreatable individuals.

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