Open AccessArabidopsis proteins with a transposon-related domain act in gene silencing
Author(s) -
Yoko Ikeda,
Thierry Pélissier,
Pierre Bourguet,
Claude Becker,
Marie Noëlle Pouch-Pélissier,
Romain Pogorelcnik,
Magdalena Weingartner,
Detlef Weigel,
Jean-Marc Deragon,
Olivier Mathieu
Publication year - 2017
Publication title -
nature communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.559
H-Index - 365
ISSN - 2041-1723
DOI - 10.1038/ncomms15122
Subject(s) - transposable element , gene silencing , arabidopsis , biology , dna methylation , genetics , retrotransposon , gene , heterochromatin , argonaute , rna interference , genome , computational biology , gene expression , mutant , chromatin , rna
Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and MAIN define an alternative silencing pathway independent of DNA methylation and short interfering RNAs. Mutants for MAIL1 or MAIN exhibit release of silencing and appear to show impaired condensation of pericentromeric heterochromatin. Phylogenetic analysis suggests not only that MAIL1 and MAIN encode a retrotransposon-related plant mobile domain, but also that host plant mobile domains were captured by DNA transposons during plant evolution. Our results reveal a role for Arabidopsis proteins with a transposon-related domain in gene silencing.