The fungal-specific β-glucan-binding lectin FGB1 alters cell-wall composition and suppresses glucan-triggered immunity in plants | Zendy

Stephan Wawra | Zendy; Philipp Fesel | Zendy; Heidi Widmer | Zendy; Malte Timm | Zendy; Jürgen Seibel | Zendy; Lisa Leson | Zendy; Leona Kesseler | Zendy; Robin Nostadt | Zendy; Magdalena Hilbert | Zendy; Gregor Langen | Zendy; Alga Zuccaro | Zendy

Open Access

The fungal-specific β-glucan-binding lectin FGB1 alters cell-wall composition and suppresses glucan-triggered immunity in plants

Author(s) -

Stephan Wawra,

Philipp Fesel,

Heidi Widmer,

Malte Timm,

Jürgen Seibel,

Lisa Leson,

Leona Kesseler,

Robin Nostadt,

Magdalena Hilbert,

Gregor Langen,

Alga Zuccaro

Publication year - 2016

Publication title -

nature communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.559

H-Index - 365

ISSN - 2041-1723

DOI - 10.1038/ncomms13188

Subject(s) - glucan , cell wall , innate immune system , c type lectin , lectin , biochemistry , biology , isothermal titration calorimetry , beta glucan , arabidopsis , oxylipin , immunity , nicotiana benthamiana , microbiology and biotechnology , chemistry , immune system , gene , genetics , receptor , mutant

β-glucans are well-known modulators of the immune system in mammals but little is known about β-glucan triggered immunity in planta . Here we show by isothermal titration calorimetry, circular dichroism spectroscopy and nuclear magnetic resonance spectroscopy that the FGB1 gene from the root endophyte Piriformospora indica encodes for a secreted fungal-specific β-glucan-binding lectin with dual function. This lectin has the potential to both alter fungal cell wall composition and properties, and to efficiently suppress β-glucan-triggered immunity in different plant hosts, such as Arabidopsis , barley and Nicotiana benthamiana . Our results hint at the existence of fungal effectors that deregulate innate sensing of β-glucan in plants.

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