Open AccessEndoglin moves and shapes endothelial cells
Author(s) -
Victoria L. Bautch
Publication year - 2017
Publication title -
nature cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 11.38
H-Index - 369
eISSN - 1476-4679
pISSN - 1465-7392
DOI - 10.1038/ncb3543
Subject(s) - endoglin , microbiology and biotechnology , endothelial stem cell , receptor , cell , mutant , co receptor , blood vessel , biology , chemistry , endocrinology , stem cell , biochemistry , gene , cd34 , in vitro
Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGFβ/BMP co-receptor endoglin, leading to arteriovenous shunts. Endoglin coordinates endothelial cell responses to ligand-receptor signalling and flow-mediated mechanical cues.
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