Hallmarks of pluripotency | Zendy

Alejandro De Los Angeles | Zendy; Francesco Ferrari | Zendy; Ruibin Xi | Zendy; Yuko Fujiwara | Zendy; Nissim Benvenisty | Zendy; Hongkui Deng | Zendy; Konrad Hochedlinger | Zendy; Rudolf Jaenisch | Zendy; Soohyun Lee | Zendy; Harry G. Leitch | Zendy; M. William Lensch | Zendy; Ernesto Lujan | Zendy; Duanqing Pei | Zendy; Janet Rossant | Zendy; Marius Wernig | Zendy; Peter J. Park | Zendy; George Q. Daley | Zendy

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Hallmarks of pluripotency

Author(s) -

Alejandro De Los Angeles,

Francesco Ferrari,

Ruibin Xi,

Yuko Fujiwara,

Nissim Benvenisty,

Hongkui Deng,

Konrad Hochedlinger,

Rudolf Jaenisch,

Soohyun Lee,

Harry G. Leitch,

M. William Lensch,

Ernesto Lujan,

Duanqing Pei,

Janet Rossant,

Marius Wernig,

Peter J. Park,

George Q. Daley

Publication year - 2015

Publication title -

nature

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 15.993

H-Index - 1226

eISSN - 1476-4687

pISSN - 0028-0836

DOI - 10.1038/nature15515

Subject(s) - induced pluripotent stem cell , biology , stem cell , epigenetics , computational biology , embryonic stem cell , cellular differentiation , microbiology and biotechnology , cell potency , functional genomics , genomics , genetics , gene , genome

Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.

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