Richness of human gut microbiome correlates with metabolic markers | Zendy

Emmanuelle Le Chatelier | Zendy; Trine Nielsen | Zendy; Junjie Qin | Zendy; Edi Prifti | Zendy; Falk Hildebrand | Zendy; Gwen Falony | Zendy; Mathieu Almeida | Zendy; Manimozhiyan Arumugam | Zendy; Jean-Michel Batto | Zendy; Sean Kennedy | Zendy; Pierre Léonard | Zendy; Junhua Li | Zendy; Kristoffer Sølvsten Burgdorf | Zendy; Niels Grarup | Zendy; Torben Jørgensen | Zendy; Ivan Brandslund | Zendy; Henrik Bjørn Nielsen | Zendy; Agnieszka Sierakowska Juncker | Zendy; Marcelo Bertalan | Zendy; Florence Levenez | Zendy; Nicolas Pons | Zendy; Simon Rasmussen | Zendy; Shinichi Sunagawa | Zendy; Julien Tap | Zendy; Sebastian Tims | Zendy; Erwin G. Zoetendal | Zendy; Søren Brunak | Zendy; Karine Clément | Zendy; Joël Doré | Zendy; Michiel Kleerebezem | Zendy; Karsten Kristiansen | Zendy; Pierre Renault | Zendy; Thomas Sicheritz-Pontén | Zendy; Willem M. de Vos | Zendy; Jean-Daniel Zucker | Zendy; Jeroen Raes | Zendy; Torben Hansen | Zendy; Éric Guédon | Zendy; Christine Delorme | Zendy; Séverine Layec | Zendy; Ghalia Khaci | Zendy; Maarten van de Guchte | Zendy; Gaetana Vandemeulebrouck | Zendy; Alexandre Jamet | Zendy; Rozenn Dervyn | Zendy; Nicolás Sánchez | Zendy; Emmanuelle Maguin | Zendy; Florence Haimet | Zendy; Yohanan Winogradski | Zendy; Antonella Cultrone | Zendy; Marion Leclerc | Zendy; Catherine Juste | Zendy; Hervé M. Blottière | Zendy; Éric Pelletier | Zendy; Denis Lepaslier | Zendy; François Artiguenave | Zendy; Thomas Brüls | Zendy; Jean Weissenbach | Zendy; A. Keith Turner | Zendy; Julian Parkhill | Zendy; Maria Antolı́n | Zendy; Chaysavanh Manichanh | Zendy; Francesc Casellas | Zendy; Natalia Boruel | Zendy; Encarna Varela | Zendy; Antonio Torrejón | Zendy; Francisco Guarner | Zendy; Gérard Denariaz | Zendy; Muriel Derrien | Zendy; Johan E. T. van Hylckama Vlieg | Zendy; Patrick Veiga | Zendy; Raish Oozeer | Zendy; Jan Knol | Zendy; María Rescigno | Zendy; Christian Bréchot | Zendy; Christine M’Rini | Zendy; Alexandre Mérieux | Zendy; Takuji Yamada | Zendy; Peer Bork | Zendy; Jun Wang | Zendy; S. Dusko Ehrlich | Zendy; Oluf Pedersen | Zendy

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Richness of human gut microbiome correlates with metabolic markers

Author(s) -

Emmanuelle Le Chatelier,

Trine Nielsen,

Junjie Qin,

Edi Prifti,

Falk Hildebrand,

Gwen Falony,

Mathieu Almeida,

Manimozhiyan Arumugam,

Jean-Michel Batto,

Sean Kennedy,

Pierre Léonard,

Junhua Li,

Kristoffer Sølvsten Burgdorf,

Niels Grarup,

Torben Jørgensen,

Ivan Brandslund,

Henrik Bjørn Nielsen,

Agnieszka Sierakowska Juncker,

Marcelo Bertalan,

Florence Levenez,

Nicolas Pons,

Simon Rasmussen,

Shinichi Sunagawa,

Julien Tap,

Sebastian Tims,

Erwin G. Zoetendal,

Søren Brunak,

Karine Clément,

Joël Doré,

Michiel Kleerebezem,

Karsten Kristiansen,

Pierre Renault,

Thomas Sicheritz-Pontén,

Willem M. de Vos,

Jean-Daniel Zucker,

Jeroen Raes,

Torben Hansen,

Éric Guédon,

Christine Delorme,

Séverine Layec,

Ghalia Khaci,

Maarten van de Guchte,

Gaetana Vandemeulebrouck,

Alexandre Jamet,

Rozenn Dervyn,

Nicolás Sánchez,

Emmanuelle Maguin,

Florence Haimet,

Yohanan Winogradski,

Antonella Cultrone,

Marion Leclerc,

Catherine Juste,

Hervé M. Blottière,

Éric Pelletier,

Denis Lepaslier,

François Artiguenave,

Thomas Brüls,

Jean Weissenbach,

A. Keith Turner,

Julian Parkhill,

Maria Antolı́n,

Chaysavanh Manichanh,

Francesc Casellas,

Natalia Boruel,

Encarna Varela,

Antonio Torrejón,

Francisco Guarner,

Gérard Denariaz,

Muriel Derrien,

Johan E. T. van Hylckama Vlieg,

Patrick Veiga,

Raish Oozeer,

Jan Knol,

María Rescigno,

Christian Bréchot,

Christine M’Rini,

Alexandre Mérieux,

Takuji Yamada,

Peer Bork,

Jun Wang,

S. Dusko Ehrlich,

Oluf Pedersen

Publication year - 2013

Publication title -

nature

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 15.993

H-Index - 1226

eISSN - 1476-4687

pISSN - 0028-0836

DOI - 10.1038/nature12506

Subject(s) - species richness , biology , gut flora , microbiome , obesity , population , zoology , ecology , immunology , genetics , medicine , endocrinology , environmental health

We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

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