How cancer metabolism is tuned for proliferation and vulnerable to disruption | Zendy

Almut Schulze | Zendy; Adrian L. Harris | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

How cancer metabolism is tuned for proliferation and vulnerable to disruption

Author(s) -

Almut Schulze,

Adrian L. Harris

Publication year - 2012

Publication title -

nature

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 15.993

H-Index - 1226

eISSN - 1476-4687

pISSN - 0028-0836

DOI - 10.1038/nature11706

Subject(s) - cancer , reprogramming , cancer cell , identification (biology) , biology , computational biology , bioinformatics , signalling pathways , metabolic pathway , cancer treatment , cancer research , metabolism , signal transduction , microbiology and biotechnology , genetics , biochemistry , cell , ecology

Cancer metabolism has received a substantial amount of interest over the past decade. The advances in analytical tools have, along with the rapid progress of cancer genomics, generated an increasingly complex understanding of metabolic reprogramming in cancer. As numerous connections between oncogenic signalling pathways and metabolic activities emerge, the importance of metabolic reprogramming in cancer is being increasingly recognized. The identification of metabolic weaknesses of cancer cells has been used to create strategies for treating cancer, but there are still challenges to be faced in bringing the drugs that target cancer metabolism to the clinic.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research