Circadian topology of metabolism | Zendy

Joseph Bass | Zendy

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Circadian topology of metabolism

Author(s) -

Joseph Bass

Publication year - 2012

Publication title -

nature

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 15.993

H-Index - 1226

eISSN - 1476-4687

pISSN - 0028-0836

DOI - 10.1038/nature11704

Subject(s) - biological clock , biology , biological organism , circadian rhythm , neuroscience , function (biology) , sleep (system call) , chronobiology , arousal , molecular clock , circadian clock , evolutionary biology , topology (electrical circuits) , computer science , genetics , gene , biological system , biological materials , phylogenetics , operating system , mathematics , combinatorics

Biological clocks are genetically encoded oscillators that allow organisms to anticipate changes in the light-dark environment that are tied to the rotation of Earth. Clocks enhance fitness and growth in prokaryotes, and they are expressed throughout the central nervous system and peripheral tissues of multicelled organisms in which they influence sleep, arousal, feeding and metabolism. Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand to analyse their function in health and disease at the cellular and molecular level.

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